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Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in

Frontiers of Medicine   Pages 939-956 doi: 10.1007/s11684-023-0987-9

Abstract: To this end, 12 645 cardiac cells were generated from embryonic day 17.5 and postnatal days 2 and 8 miceThree cardiac developmental paths were identified: two switching to cardiomyocytes (CM) maturation withclose CM–fibroblast (FB) communications and one maintaining MNDCM status with least CM–FB communicationsThese findings could improve the understanding of MNDCM heterogeneity and cardiac development, thus providingnew clues for approaches to effective cardiac regeneration.

Keywords： mononuclear diploid cardiomyocytes     cell–cell communication     cardiac fibroblast     single-cell RNA sequencing     cardiac regeneration    

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Integrated management of cardiac failure: the cardiac failure clinic

Daniel LOISANCE

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 20-25 doi: 10.1007/s11684-011-0106-1

Abstract:

The prevalence of the risk factors and the risk of cardiac failure are both increasing in China.The wide range of clinical presentations of cardiac failure (acute or chronic) and of therapeutic approachesintegration within the same structure of the various experts involved in the diagnosis and the treatment of cardiacIn these centers, collaboration should replace competition between the medical and the surgical cardiac

Keywords： cardiac failure     cardiac transplantation     mechanical circulatory support    

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Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 58-67 doi: 10.1007/s11684-022-0937-y

Abstract: Kaplan–Meier estimates showed that recipients with cardiac abnormalities had a significantly increasedAfter adjusting for potential confounders, cardiac abnormality was shown to be independently associated

Keywords： cardiac disease     mortality     aged population     lung transplantation    

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Management of mantle cell leukemia with cardiac involvement leading to cardiogenic shock

Muhammad Furqan,Yamei Chen,Akintunde Akinleye,Judy Sarungbam,Alan Gass,Karen Seiter,Delong Liu

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 254-258 doi: 10.1007/s11684-014-0319-1

Abstract: Here we report a case of cardiac involvement by mantle cell leukemia leading to cardiogenic shock which

Keywords： mantle cell lymphoma     bendamustine     cardiogenic shock    

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Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy

ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 19-24 doi: 10.1007/s11684-008-0005-2

Abstract: the effects of RNA interference (RNAi) targeting angiotensin 1a receptor (AT1a) on blood pressure and cardiactargeting AT1a receptor inhibits the development of renovascular hypertension and the accompanying cardiac

Keywords： therapy     Sprague     administration     cardiac hypertrophy     valsartan    

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Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 445-455 doi: 10.1007/s11684-014-0378-3

Abstract: In control mice, 4 weeks of TAC induced significant cardiac dysfunction, cardiac fibrosis, and cardiacfibroblast activation (proliferation and transformation to myofibroblasts).Sildenafil treatment markedly prevented TAC-induced cardiac dysfunction, cardiac fibrosis and cardiacfibroblast activation but did not block TAC-induced transforming growth factor-β1 (TGF-β1)In isolated cardiac fibroblasts, sildenafil blocked TGF-β1-induced cardiac fibroblast transformation

Keywords： PDE5     cardiac fibrosis     TGF-β     CREB    

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Evidence for lung repair and regeneration in humans: key stem cells and therapeutic functions of fibroblast

Xuran Chu, Chengshui Chen, Chaolei Chen, Jin-San Zhang, Saverio Bellusci, Xiaokun Li

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 262-272 doi: 10.1007/s11684-019-0717-5

Abstract: of these cells, such as basal cells, broncho-alveolar stem cells, and alveolar type 2 cells, rely on fibroblast

Keywords： FGF     human lung     repair     regeneration     stem cells    

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Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 444-456 doi: 10.1007/s11684-015-0421-z

Abstract: Changes in the cardiac structure and function were assessed through echocardiography and transmission

Keywords： aspirin     Akt     cardiac hypertrophy     GSK-3β     Wnt/β-catenin    

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PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 399-403 doi: 10.1007/s11684-014-0380-9

Abstract:

We review here the novel cardiac protective effects of the multifunctional enzyme, p21-activated kinasereview, we assemble an overview of the recent findings on PAK1 signaling in the heart, particularly its cardiacWe present a model for PAK1 signaling that provides a mechanism for specifically affecting cardiac cellularWe discuss the anti-adrenergic and antihypertrophic cardiac protective effects of PAK1, as well as its

Keywords： p21-activated kinase 1 (PAK1)     heart    

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FGF23 associated bone diseases

Eryuan Liao

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 65-80 doi: 10.1007/s11684-013-0254-6

Abstract:

Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potential

Keywords： fibroblast growth factor 23     FGF receptor     phosphate metabolism     Klotho     bone disease    

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Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

Huating Li, Jing Zhang, Weiping Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 25-30 doi: 10.1007/s11684-013-0244-8

Abstract:

Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor family.

Keywords： FGF21     metabolism     pharmacology     physiology     clinical relevance    

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Right coronary occlusion following transcatheter aortic valve implantation: two case reports

Gang Zhang,Jun Luo,Guo Chen

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 351-355 doi: 10.1007/s11684-016-0465-8

Abstract:

This paper discusses two male patients with severe aortic stenosis, whose right coronary arteries (RCA) were completely occluded during transcatheter aortic valve implantation (TAVI), leading to fatal hemodynamic disorder. Occlusions of RCA complicated by TAVI are rare. In addition, emergency cardiopulmonary bypass (CPB) played a critical role in rescuing our second patient. Both patients were admitted for “severe aortic stenosis,” and TAVIs were performed. The first patient’s blood pressure immediately dropped to 70/40 mmHg after the balloon expansion and did not increase much after the administration of aramine or fluid therapy. He did not receive emergency surgery and died after 1.5 h of resuscitation. The second patient’s blood pressure fluctuated greatly for several minutes after the valve implantation, ranging from 170/100 mmHg to 60/40 mmHg. Angiography revealed a total occlusion of RCA. Thoracic surgery with CPB was performed, and the patient survived.

Keywords： aortic stenosis     transcatheter aortic valve implantation     right coronary occlusion     cardiac group    

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Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications

Aixiu Qiao,Feng Gu,Xiaojing Guo,Xinmin Zhang,Li Fu

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 33-40 doi: 10.1007/s11684-016-0431-5

Abstract:

Breast cancer is the most common malignant tumor in women, and the incidence of this disease has increased in recent years because of changes in diet, living environment, gestational age, and other unknown factors. Previous studies focused on cancer cells, but an increasing number of recent studies have analyzed the contribution of cancer microenvironment to the initiation and progression of breast cancer. Cancer-associated fibroblasts (CAFs), the most abundant cells in tumor stroma, secrete various active biomolecules, including extracellular matrix components, growth factors, cytokines, proteases, and hormones. CAFs not only facilitate the initiation, growth, angiogenesis, invasion, and metastasis of cancer but also serve as biomarkers in the clinical diagnosis, therapy, and prognosis of breast cancer. In this article, we reviewed the literature and summarized the research findings on CAFs in breast cancer.

Keywords： cancer-associated fibroblast     breast cancer     progression     prognosis    

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Cardiac Remote Conditioning and Clinical Relevance: All Together Now! Review

Kristin Luther,Yang Song,Yang Wang,Xiaoping Ren,W. Keith Jones

Engineering 2015, Volume 1, Issue 4,   Pages 490-499 doi: 10.15302/J-ENG-2015117

Abstract: cardioprotective “conditioning” phenomena represent activation from different entry points of a cardiacand nociceptive stimuli is emerging as a potential non-ischemic and non-traumatic means to initiate cardiac

Keywords： remote cardioprotection     cardiac conditioning     non-ischemic conditioning     peripheral nociceptive stimulus    

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Familial amyloid cardiomyopathy masquerading as chronic Guillain-Barre syndrome: things are not always what they seem

Die Hu, Ling Liu, Shuguang Yuan, Yuhong Yi, Daoquan Peng

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 293-296 doi: 10.1007/s11684-017-0516-9

Abstract: diseases, particularly in patients with pronounced neurological presentations and unexplained or equivocal cardiacanalysis, explained the concurrence of independent pathological features, including neuropathy and cardiac

Keywords： transthyretin (TTR) cardiac amyloidosis     sick sinus syndrome     chronic Guillain-Barre syndrome    

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Title Author Date Type Operation

Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in

Journal Article

Integrated management of cardiac failure: the cardiac failure clinic

Daniel LOISANCE

Journal Article

Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients

Journal Article

Management of mantle cell leukemia with cardiac involvement leading to cardiogenic shock

Muhammad Furqan,Yamei Chen,Akintunde Akinleye,Judy Sarungbam,Alan Gass,Karen Seiter,Delong Liu

Journal Article

Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy

ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen

Journal Article

Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Journal Article

Evidence for lung repair and regeneration in humans: key stem cells and therapeutic functions of fibroblast

Xuran Chu, Chengshui Chen, Chaolei Chen, Jin-San Zhang, Saverio Bellusci, Xiaokun Li

Journal Article

Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Journal Article

PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Journal Article

FGF23 associated bone diseases

Eryuan Liao

Journal Article

Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

Huating Li, Jing Zhang, Weiping Jia

Journal Article

Right coronary occlusion following transcatheter aortic valve implantation: two case reports

Gang Zhang,Jun Luo,Guo Chen

Journal Article

Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications

Aixiu Qiao,Feng Gu,Xiaojing Guo,Xinmin Zhang,Li Fu

Journal Article

Cardiac Remote Conditioning and Clinical Relevance: All Together Now!

Kristin Luther,Yang Song,Yang Wang,Xiaoping Ren,W. Keith Jones

Journal Article

Familial amyloid cardiomyopathy masquerading as chronic Guillain-Barre syndrome: things are not always what they seem

Die Hu, Ling Liu, Shuguang Yuan, Yuhong Yi, Daoquan Peng

Journal Article